Stocks snap 4-day winning streak as coronavirus vaccine, treatment hit snags

Stocks ended lower Tuesday, snapping a four-day winning streak for major indexes, as investors weighed separate setbacks in trials for a COVID-19 vaccine and a treatment and sifted through earnings for big Wall Street banks. The Dow Jones Industrial Average DJIA, -0.54% fell around 157 points, or 0.5%, to end near 28,681, while the S&P 500 SPX, -0.63% gave up around 22 points, or 0.6%, finishing near 3,512. The Nasdaq Composite COMP, -0.10% closed near 11,864, down 97 points, or 0.8%. Shares of Johnson & Johnson JNJ, -2.29% fell 2.9% after Stat News reported that the drug maker had paused its COVID-19 vaccine trial over an “unexplained illness.” Later Tuesday, Eli Lilly & Co. LLY, -2.85% confirmed that a data safety monitoring board had paused enrollment in a clinical study testing its experimental COVID-19 monoclonal antibody treatment in combination with Gilead Sciences Inc.’s GILD, -0.09% remdesivir. Eli Lilly shares ended 2.9% lower.

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